The Novavax COVID-19 vaccine (Nuvaxovid) is for people aged 12 and over who wish to have a different COVID-19 vaccine option. Novavax Booster Recommendation Nevertheless, NVX-CoV2373s existing safety profile is encouraging thus far, noted Dr Daniel Griffin, chief of New York-based ProHealth Healthcares Division of Infectious Disease. In recent months, vaccine demand has been on the decline, hurting Novavaxs prospects. Youre reading a free article with opinions that may differ from The Motley Fools Premium Investing Services. Teenagers ages 12 through 17 who had the Novavax primary series must get a Pfizer-BioNTech bivalent booster. Then the spike protein is extracted once it is produced in the cells. Tell them youve had a COVID-19 vaccination so they can assess you properly. Were much more familiar with protein vaccines.'. We take your privacy seriously. Medical News Today has contacted over 20 experts for comment on the potential side effects of the Novavax COVID-19 vaccine, Nuvaxovid. More data is needed regarding NVX-CoV2373s potential to induce immunological memory to further its argument as the ideal booster, added Alabama Vaccine Research Clinic director Dr Paul Goepfert. Adria Cimino has no position in any of the stocks mentioned. Belongia pointed to the Com-COV trial data showing SARS-CoV-2 antispike IgG concentrations of heterologous vaccines being higher than homologous schedules. If you're a shareholder, you might consider holding instead of selling at a loss. Any side effects from the vaccine were largely mild to moderate and transient. Sinopharm COVID-19 vaccine: Should you worry about the side effects? It is also available as a booster at least 6 months after completing the primary course for any of the COVID-19 vaccines available in New Zealand. Interpretation services are available if you need them. But here, too, Novavax won regulatory nods after rivals Pfizer and Moderna. New vaccines for COVID-19 are emerging. A woman is seen receiving a vaccination at a Cohealth pop-up vaccination clinic at the State Library Victoria in Melbourne. The Novavax is a protein based shot, unlike previous shots. Novavax has a version of its vaccine specific for the Beta variant of concern in preclinical investigations. Novavax is currently marketing two versions of NVX-CoV2373 one in partnership with . On a new IBD podcast, Jon Najarian explains 0DTE options and their unintended impact. Data to date do not demonstrate concerning safety signals. But Novavax went on to disappoint investors. U.S. regulators on Wednesday granted emergency use authorization for the COVID-19 vaccine made by Novavax to be used as a booster. This is despite the companys booster positioning being a sound market tactic in certain countries, experts said. The data also provide a finely detailed picture of . At the same time, Novavax's expenses have climbed due to the costs of . It's recommended that you do not have Novavax if you have had a severe allergic reaction (e.g. At the same time, Novavax's expenses have climbed due to. In interviews, Novavax CEO Stanley Erck has said the vaccines use as a booster might be its biggest market in the US. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. And investors bet on the company's ability to bring its vaccine candidate to market. Both the U.K. and the US. Novavax has submitted an application to the Food and Drug Administration for Emergency Use Authorization of its COVID-19 vaccine as a booster in adults that can be used on top of its primary vaccine series or to mix and match with a different primary series, the company announced. Avenue Therapeutics Buys Baergic Bio, Beefs Up Central Nervous System-Focused Portfolio, Ocuphire Pharma Shares Jump After Global Licensing Pact For Nyxol Eye Drops, What In The World Is Going On With Dogecoin Rival Shiba Inu (SHIB) Falling Suddenly? While the Pfizer and Moderna shots rely on messenger RNA platforms, Novavax's shot is protein-based. Adjuvants are manufactured separately. U.S. regulators on Wednesday authorized a booster dose of the COVID-19 vaccine made by Novavax. Novavax has delayed its US application several times due to manufacturing checks and its filing is now anticipated in Q4. After a second dose of the Pfizer vaccine : 66% reported pain Trump wants 'Freedom Cities' where cars can fly, parents get 'BONUSES' for having babies and huge monuments are built to 'true American heroes' in 'Quantum Leap' vision for the future. Novavax on Tuesday disclosed results from a late-stage clinical trial testing updated versions of its COVID-19 vaccine, weeks after the data were originally expected to be available.. Study results showed a bivalent booster targeting the BA.1 and BA.5 omicron strains of the coronavirus failed to raise antibody levels by more than Novavax's current vaccine or a monovalent vaccine aimed solely . Novavax was the first protein-based COVID vaccine to have been approved in Australia. FDA officials flagged four cases of myocarditis and pericarditis swelling in a membrane surrounding the heart from Novavax's clinical trial in young men ages 16 to 28. Novavax currently sells just one drug, the Covid vaccine. Even though NVX-CoV2373s trials recruited thousands of participants, the rare side effects seen with mRNA and adenovirus-vectored Covid-19 vaccines only surfaced once millions of people were vaccinated, and this could also be the case with NVX-CoV2373, added Midwest Biomedical Research chief scientist Dr Kevin Maki. This Snapshot feature outlines the known side effects of CoronaVac, the COVID-19 vaccine developed by Chinese biotechnology company Sinovac. Sinovac COVID-19 vaccine: What are the side effects? Learn More. A UK phase 2 trial shows that different COVID-19 booster shots are safe and boost immunity when given 10 to 12 weeks after two doses of the AstraZeneca/Oxford or Pfizer/BioNTech vaccines, although immune responses varied widely.. Additionally, there is a disproportionate burden of COVID-19 infections and deaths among racial and ethnic minority communities. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. A rare head-to-head comparison shows that the COVID-19 vaccines made by Pfizer and Moderna outperform those from Johnson & Johnson and Novavax 1. Recommendations for adults who are moderately or severely immunocompromised are shown below by primary series and includes 3-dose Moderna and Pfizer series in the first row, 2-dose Novavax in the second row, and Janssen single-dose primary series in the third row. Is the intervention feasible to implement? Clostridioides difficile Infections Drugs in Development by Benign Prostatic Hyperplasia Drugs in Development by Stages, LOA and PTSR Model - herpes zoster vaccine. 'Here We Go Again': Seagen Soars As Pfizer Reportedly Mulls A Takeover, Reata Stock Plummets As Official's Exit Shakes Up FDA's Neuroscience Unit, Looking For The Next Big Stock Market Winners? A first booster dose is recommended 4-6 months after the completion of the primary series. If these symptomsdont go away, seek medical help again. Novavax's vaccine uses a traditional mechanism as compared to mRNA vaccines. The BA.5 strain pseudoneutralization responses demonstrated no benefit for the BA.1 or bivalent vaccine candidates compared to the prototype vaccine in the overall trial population. Thank you for taking the time to confirm your preferences. Serious adverse events after the booster dose were reported by 43/12,777 participants (0.3%). Ifyou get any of these new symptoms after your vaccination, you shouldseek prompt medical help. While they share COVID-19s molecular structure, they do not replicate or cause COVID-19. People who received Pfizer, Moderna or J&J as their primary series can also receive Novavax as their first booster if they want. Nearly everyone 6 months and older needs an updated ( bivalent) vaccine to stay up to date with COVID-19 vaccines. We are no longer accepting comments on this article. In this Snapshot, we take a closer look at the potential side effects associated with the Oxford-AstraZeneca COVID-19 vaccine, also known as Vaxzevria. Related:FDA Gives Emergency Nod To Novavax's Adjuvanted COVID-19 Booster Dose. Possible side effects: Injection site tenderness, fatigue, headache, muscle pain. When a person is given the vaccine, their body will react by producing antibodies . Since then, the company hasn't been able to carve out much market share, and the stock has plummeted. The data demonstrate that the BA.1 vaccine candidate neutralizing responses in those not previously exposed to COVID-19 were greater than those of the prototype vaccine. To manufacture protein subunit vaccines, insect cells are grown in large volumes over several weeks, and then infected with baculoviruses that contain the genetic code for the spike protein, Kis explained. Novavax differs from mRNA vaccines like Pfizer and Moderna but all have similar side effects after a person is jabbed. Most side effects are mild and goaway within a few days. But to reach success with that potential product, Novavax must have the financial strength to survive. Covaxin COVID-19 vaccine: What to know about side effects. You will need to stay for at least 15 minutes so a healthcare worker can look out for you and make sure you are ok. Once the healthcare worker is confident that youre fine and you are feeling ok, you can leave and carry on with your day. Pfizer vaccine for COVID-19: What are the side effects? Moderna and Pfizer's shots use mRNA technology that uses nucleic acid to generate a spike protein that imitates that of what the. The Pfizer COVID-19 vaccine is the preferred option for someone who is pregnant, trying to get pregnant, or breastfeeding. Novavax (NVAX) says there's "substantial doubt" regarding its ability to continue, and NVAX stock crashed Wednesday. A year of Russias war in Ukraine: who is winning the battle on clinical trials? You will require a prescription for your second primary dose if your first primary dose was not Novavax. However, protection is highest in adults who receive all recommended booster doses.3 About 48% of adults, which is approximately 96 million, are eligible for a booster and have not yet received a booster.4. During the December quarter, the company brought in $357 million in sales accounting for growth in its Covid vaccine, Nuvaxovid, offset by declining revenue from grants, royalties and other sources. The safety of a single booster dose of the Pfizer-BioNTech COVID-19 Vaccine, Bivalent for individuals 12 years of age and older is based on safety data from a clinical study which evaluated a . Despite delivery of 841,300 doses, Novavax uptake has been limited in the United States. Try these 11 riddles ChatGPT ALMOST aced, The troubled action hero: Tom Sizemore boasted of affairs with Liz Hurley and Paris Hilton (which he had to admit was a lie), attacked his wife actress Maeve Quinian and LA madam Heidi Fleiss - as he battled drink and drugs before his death at 61, Tom Sizemore, 61, dies after aneurysm and stroke: Action star known for Saving Private Ryan, Black Hawk Down and Born on the Fourth of July battled addiction, Are YOU guilty of these gym sins? Can Earnings Recharge Electric Vehicle Stocks? The Novavax COVID-19 vaccine is an adjuvanted protein-based vaccine. Pfizer, Moderna, or Novavax COVID-19 vaccines are preferred over Johnson & Johnson's COVID-19 vaccine in most situations. Learn all the ways IBDs top investing tools can help you succeed in the market! Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The Food and Drug Administration has authorized Novavax's shot as a primary series for people age 12 and older, and as a booster shot in adults. *Average returns of all recommendations since inception. 'You still have then the production of antibodies (with Novavax).'. COVID-19 remains a significant threat, killing nearly 350 Americans per day.2 Being up to date with COVID-19 vaccines continues to provide strong protection against severe disease, hospitalization, and death in adults, including during Omicron variant predominance. Make more money in stocks with 2 months of access to IBD Digital for only $20! Get market updates, educational videos, webinars, and stock analysis. In the study, the first randomized trial of COVID-19 booster-provoked immune response, a team led by University of Southampton researchers evaluated safety and immune . 1. Novavax in March 2020 reported favourable safety data from its Phase III Nanoflu trial in adults aged 65 years and over. A fully-trained healthcare worker will then give you the vaccine in your upper arm. Invest better with The Motley Fool. Novavax's vaccine manufacturing process takes more time than that of Pfizer and Moderna. Is it time to give up on this embattled stock? It is given as an intramuscular jab like other COVID-19 vaccines, with two doses given three weeks apart. The updated vaccine gives you increased protection against Omicron variants which . Novavaxs vaccine made it to market much later than rivals -- and the company lost out on peak demand. Prescriptions are not required for either a first or second Novavax booster dose. Novavax stock has dropped about 97% since its peak in 2021. Novavaxs Covid-19 vaccine could find its niche as a booster shot, but questions linger around its safety and production. Notice: Information contained herein is not and should not be construed as an offer, solicitation, or recommendation to buy or sell securities. The Food and Drug Administration said the new booster option is for people 18 and older who can't get the updated omicron-targeting Pfizer or Moderna boosters for medical or accessibility reasons -- or who otherwise would not receive a COVID-19 booster shot at all. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. The company indicates its supply lines. Now, the Centers for Disease Control and Prevention (CDC) have recommended Novavax's COVID-19 vaccine as a mix-and-match booster dose after a primary series of Pfizer-BioNTech, Moderna, or Johnson & Johnson. tightness, heaviness, discomfort or pain in your chest or neck, difficulty breathing or catching your breath. Test your knowledge by naming all 20 of these famous films, 'It's my prerogative': Idris Elba HITS BACK at being criticized for not wanting to call himself a 'black actor' after sparking race debate, Are YOU smarter than a machine? "Given these uncertainties, substantial doubt exists regarding our ability to continue," the company said in its earnings report. It won regulatory authorization a year after rivals, so it missed out on the initial big wave of demand and sales. The shot is given six months after the primary vaccine to adults only if they have not received any booster shot previously, and they cannot receive a Pfizer-BioNTech or Moderna mRNA bivalent booster for a medical or any other reason. You can get a prescription at the vaccinating Novavax clinic or prior to your appointment with your preferred GP. Finally, the U.S. government has said its funding agreement with Novavax wouldn't continue beyond the end of this year. Follow Allison Gatlin on Twitter at @IBD_AGatlin. This type of vaccine contains an antigen (protein) that's unique to a germ. The information has been obtained from sources we believe to be reliable; however no guarantee is made or implied with respect to its accuracy, timeliness, or completeness. This is a recognised risk with the Comirnaty (Pfizer) and Spikevax (Moderna) vaccines and we are closely monitoring these events. Meanwhile, in Europe, NVX-CoV2373 is in a rolling review process. Now, the biotech is making big efforts to cut costs and turn today's difficult situation around. Alastair Grant, Associated Press. "The U.S. now has access to the Novavax COVID-19 Vaccine, Adjuvanted, the first protein-based option, as a booster," Novavax President and CEO Stanley Erck said in a news release Wednesday . According to Dr. Peter English, a retired consultant in communicable disease control, former editor of Vaccines in Practice, and immediate past chair of the BMA Public Health Medicine Committee: [t]he vaccine is a much more traditional sort of vaccine than the mRNA and vector vaccines currently in use. On Tuesday, the Centers for Disease Control and Prevention (CDC) endorsed the Food and Drug Administration's emergency approval of Novavax, a new COVID-19 vaccine that used a more old-fashioned method in its development, one that might be embraced by anyone leery of the Pfizer and Moderna mRNA vaccines. In accordance with the WHO Prioritization Roadmap, the highest priority . All rights reserved. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Today, Novavax's vaccine may be used as a booster. And that means Novavax could miss out on more than $400 million. 2 Dec 21 (Reuters) - Novavax said on Tuesday the World Health Organization's (WHO) panel of experts had recommended a third dose of its vaccine, NVX-CoV2373, for immunocompromised persons. Novavax can also be used as a booster dose in people aged 18 years and older. Moderna and Pfizer's shots use mRNA technology that uses nucleic acid to generate a spike protein that imitates that of what the virus uses to infect a person's cells. Unlike the latest boosters from Pfizer-BioNTech and Moderna, which. It is to be administered at least six months after a person has completed a primary COVID-19 vaccine series. Both Pfizer's and Moderna's vaccines use messenger RNA (mRNA) to deliver a blueprint of sorts to cells in the body. It's pure protein, there is no nucleic acid that is injected into your body. Overall evidence: Strong. Once more, if adults who are moderately or severely immunocompromised are unable or unwilling to get a bivalent mRNA booster, a monovalent Novavax booster dose is recommended at least 6 months after the primary series only without receipt of a previous booster(s). But Covid vaccinations in the U.S. are waning. Vaccinations are slowing and the public health emergency in the U.S. is now slated to end in May. 2022 Benzinga.com. Medical conditions that may prevent a person using mRNA vaccines include anaphylaxis and myocarditis where the heart becomes inflamed. The Novavax is a protein based shot, unlike previous shots. While the vaccines developed by Pfizer-BioNTech and Moderna use mRNA, Novavax is a traditional protein-based vaccine that contains the spike protein from SARS-CoV-2, the virus that causes. Cookies used to make website functionality more relevant to you. Cost basis and return based on previous market day close. . A small number of myocarditis and pericarditis cases have been reported for booster doses. Your immune system may not respond as strongly to the spike protein on its own. There is no authorised protein subunit Covid-19 vaccine in the US and Europe, and NVX-CoV2373 is the frontrunner. If you feel any of these symptoms in the days or weeks after the vaccine, you should see a healthcare professional, such as aGP, afterhours service or emergency department there will be no charge for the consultation. To make the world smarter, happier, and richer. However, they recommend pregnant people get vaccinated in situations where the benefits outweigh the risks. Realtime quote and/or trade prices are not sourced from all markets. Novavax's COVID-19 vaccine is for people age 12 and older who haven't received any COVID-19 vaccine yet. Novavax, Inc. NVAX shares are trading lower by 6.76% to $32.84 Wednesday afternoon in possible reaction to competitor Moderna Inc MRNA receiving FDA authorization for emergency use of its. In recent times, headwinds have multiplied. The Novavax booster vaccine may only be used as a first booster, meaning that anyone who has already had one or multiple booster doses of the Pfizer-BioNTech and/or Moderna vaccines may not receive the Novavax booster at this time. Countries like Germany, Israel, the UK, and the US are deep into planning or executing booster deployment, despite the World Health Organization (WHO) calling for a delay due to worldwide vaccine shortages. TGA head professor John Skerritt said those skeptical about the mRNA vaccines like Pfizer and Moderna would likely be more comfortable being jabbed with the newly approved dose. Tech Stock In Buy Zone As It Joins Sector Leaders' Final Four, Novavax Jumps After Pledging To Update Its Covid Shot; Pfizer, Moderna Slip, Biotech Firestorm Takes Down Novavax Despite Quadrupled Sales, Why Novavax's Uphill Battle Continues Despite Winning U.S. That said, it is still unclear if using a different vaccine technology as a booster would improve efficacy as there is little data supporting that, noted Goepfert, a Phase III single-dose JNJ-78436735 investigator. Total revenue rose 73% to $1.9 billion. Saving Lives, Protecting People, Advisory Committee on Immunization Practices (ACIP), https://covid.cdc.gov/covid-data-tracker/#trends_dailycases, https://covid.cdc.gov/covid-data-tracker/#trends_dailydeaths_select_00, https://covid.cdc.gov/covid-data-tracker/#vaccine-effectiveness, https://covid.cdc.gov/covid-data-tracker/#vaccinations_vacc-people-additional-dose-totalpop, National Center for Immunization and Respiratory Diseases, Role of the ACIP in CDCs Vaccine Recommendations, Shared Clinical Decision-Making Recommendations, U.S. Department of Health & Human Services. Six different covid-19 vaccines are safe and effective to use as booster doses in people who previously received the Oxford AstraZeneca or Pfizer BioNTech vaccines, but the antibody boost they provide varies substantially, a study has found.1 The Cov-Boost trial looked at the safety, immune response, and side effects of seven vaccines when used as a third vaccine dose, often referred to as a . In an open-label continuation of the phase 3 randomized controlled trial among persons ages 18 years and older in the United States and Mexico, 12,777 participants received booster doses as of the data cut off (March 26, 2022). Novavax, in use in the U.S. since mid-2022, warned it may not survive in its latest earnings report, released after the market closed on Tuesday, CNN reported. U.S. regulators on Wednesday authorized a booster dose of the COVID-19 vaccine made by Novavax. Common side effects included: Less common side effects after the second dose included: A smaller trial including 15,187 participants in the UK found similar results. But they also call for sales to dive 36% to $1.26 billion, according to FactSet. Additional doses of the same adenovirus-vectored vaccine may not be as effective due to anti-vector response caused by the initial vaccine schedule, this news service reported 12 February. All rights reserved. Before the announcement late Tuesday, shares gained 6.8%. Part of the Daily Mail, The Mail on Sunday & Metro Media Group, Kellyanne Conway and husband George SPLIT after 22 years following admission in her 2022 memoir that her husband's criticism of Trump was a betrayal, Putin's foreign minister Sergei Lavrov provokes gales of laughter as he tells audience the West started Ukraine war - as Russia nears victory in battle for besieged city Bakhmut, EXCLUSIVE: Why diabetics should lay off the weed: 23-year-old cannabis smoker with type 1 suffered bouts of vomiting and pain for two YEARS before doctors joined the dots, Are YOU a romantic comedy buff? Early studies indicate that it may have similar efficacy to the Pfizer and Moderna vaccines but fewer side effects. Novavax would diversify vaccine options and potentially fill supply gaps. Novavaxs vaccine includes an adjuvant, which may have a different safety profile from other parts of NVX-CoV2373, said Center for Clinical Epidemiology and Population Health director Dr Edward Belongia. While Matrix-M is also in Novavaxs own influenza vaccine Nanoflu, it is yet to be a part of any approved vaccine, Belongia said. Novavax is the first protein-based COVID-19 vaccine to be approved for use in New Zealand and helps prevent you from getting infected and having COVID-19 symptoms, or severe illness. All information these cookies collect is aggregated and therefore anonymous. The company ended its purchase agreement with Gavi, saying the organization failed to order the agreed upon number of vaccine doses last year. The main difference between the Novavax vaccine and the already-approved and widely used vaccines from Pfizer/BioNTech and Moderna is the technology behind the shots. In the past, I've talked about Novavax's chances to excel in the long-term coronavirus vaccine market. Heart failure: Could a low sodium diet sometimes do more harm than good? And any good news could significantly lift the stock. Inside Scott Morrison's Covid bunker: PM sounds hoarse as he Australia is prepared to take THOUSANDS of refugees from Isabel Oakeshott receives 'menacing' message from Matt Hancock, Insane moment river of rocks falls onto Malibu Canyon in CA, Ken Bruce finishes his 30-year tenure as host of BBC Radio 2, Pavement where disabled woman gestured at cyclist before fatal crash, Pro-Ukrainian drone lands on Russian spy planes exposing location, 'Buster is next!' That would diminish from an $8.42 per-share loss in 2022. All rights reserved. Data so far suggest, that on the whole, the Novavax vaccine may have fewer side effects than both the Pfizer and Moderna vaccines. Questions on Novavaxs Covid-19 vaccine as a booster remain, given the potential for rare side effects and the need for manufacturing agility. But here, too, Novavax won regulatory nods after rivals Pfizer and Moderna. Currently, people are encouraged to stick with the same vaccine technology, even if it may mean waiting for several weeks for subsequent doses, said Edward Dougherty, a principal at his eponymous Washington DC-based healthcare consulting firm. Preliminary Phase II data showed that a single booster of NVX-CoV2373 given six months after an initial two-dose regimen of the same vaccine led to a 4.6-fold increase in antibody titers. Price Action:NVAX shares are up 3.01% at $20.01 on the last check Tuesday. Both companies predict sales of their Covid shots will decline in 2023. - SHIBA INU (SHIB/U. 2000-2023 Investor's Business Daily, LLC. Ms Bennett said because the protein was produced in a lab, researchers had to work hard to ensure there was no contamination. In relation to vaccination intentions for an adjuvanted protein subunit COVID vaccine among unvaccinated adults in the United States from January February 2022, vaccination intentions were significantly lower among non-Hispanic White adults (9.6%) than among non-Hispanic Black adults (20.1%) or among Hispanic adults (19.5%). The efficacy of Novavax against virus variants is unknown at this time. T he Food and Drug Administration announced Wednesday that it has authorized a booster shot for Novavax's Covid-19 vaccine. Rare occurrences of myocarditis or pericarditis were identified in primary series clinical trials and in global post marketing data preceding primary series authorization in the United States. At the same time, Novavax's expenses have climbed due to the costs of commercializing the vaccine. Sales grew 61%. These cookies may also be used for advertising purposes by these third parties. On the positive side, switching to Novavax as a booster is unlikely to offer lower protection compared with people who stuck with the same vaccine technology. the shingles vaccine Shingrix and influenza vaccine Fluad Quad,where a 3-day interval before or after Novavax is recommended. Also, combinations of different Covid-19 vaccine technologies have a favourable safety profile, added Ghent University Faculty of Medicine & Health Science professor emeritus Geert Leroux-Roels. The Novavax vaccine has been thoroughly assessed for safety by our own Medsafe experts. Data so far suggest, that on the whole, the Novavax vaccine may have fewer side effects than both the Pfizer and Moderna vaccines. Moderna and Pfizer's shots use mRNA technology that uses nucleic acid to generate a spike protein that imitates that of what the. The Pfizer/BioNTech and Moderna vaccines are of course mRNA-based, and that's a mode of action that had not been used in humans before. Therefore, while the Work Group reviewed data to support the recommendation, they did not determine their judgement for any of the domains listed below: Recommendations for adults who are not moderately or severely immunocompromised are shown below by primary series and includes 2-dose Moderna, Novavax, and Pfizer series in the first row and Janssen single-dose primary series in the second row.